Princess Anisphia "Anis" Wynn Palletia has always dreamed of flying through the sky, even though the people of her kingdom consider it a silly ambition. Also at odds with her goal is the fact that Anis is incapable of using magic despite her noble status. Refusing to give up so easily, she renounces her right to the throne, and focuses on developing "magicology" by combining various resources with knowledge from her previous life on Earth. Due to Anis' nature, responsibility for the kingdom's future is passed onto her younger brother, Algard. Pushed into a political marriage with Euphyllia Magenta, a girl he hardly knows, Algard rebels by spending more time with a commoner girl than his fiancée. After Euphyllia tries to intervene, Algard publicly calls off their marriage and denounces his ex-fiancée as a bully. After crashing into the banquet where Algard makes the announcement, Anis rescues Euphyllia on the flying broom she is testing. She decides to make Euphyllia her assistant, which the other girl reluctantly agrees to. Although their partnership appears random at first, Anis has an ulterior motive for wanting Euphyllia's company.

The hero king Inglis—who dedicated his entire life to building his country—is now approaching death. To award him for his honorable achievements, the goddess Alistia appears and grants him one wish. Having never been able to master the blade, Inglis asks to be reincarnated in order to do so. In a blink of an eye, Inglis finds himself born in the far future as a daughter of the Eucus noble family. Six years later, Inglis is discovered to be Runeless—incapable of utilizing the runes that enable the use of magic in this era. She is therefore ineligible to become a knight. However, this fits in well with Inglis' plan: she instead decides to become the squire for her cousin, Rafinha Bilford, allowing Inglis to focus on pushing her limits. For Inglis, the challenges this familiar yet different world has to offer are instead opportunities for her to hone her skills—and possibly become an extraordinary squire in the process.

During the final years of his life, Hiraku Machio remained confined to a hospital bed with a terminal illness until he finally passed away. Taking pity on the unfair life he lived, a god decides to reincarnate Hiraku in another world where he can live as he pleases. Wanting to try farming in this new life, he is bestowed with an all-in-one "Almighty Farming Tool" that can transform into any useful implement he wishes. Hiraku is then transported to a forest seemingly far from civilization. Here, he plans to build and farm everything from scratch—gradually developing the lifeless area into a thriving new society.

Thanks to the Fruit of Evolution, Seiichi Hiiragi's amazing new life in another world allows him to meet dependable allies and create formidable spells. His abilities catch the attention of Barnabus Ablitt, the principal of the Barbador Academy of Magic, who invites Seiichi to become a teacher at the institution. Coincidentally, Seiichi's classmates from Earth are enrolled there, which will lead to an awkward reunion if he is to meet them. Behind the scenes, however, an enigmatic cult called The Great Devil Order devises a sinister scheme to resurrect their deity and sacrifice the students of Barbador to hasten the process. As Seiichi's power is second to none, it is up to him to protect not only his friends but also the entire world from the looming darkness.