From crashing his bike to falling in lakes, Seina Yamada just cannot shake the bad luck that follows him. But his fortune begins to change when he is forcibly recruited into the Galaxy Police and ends up capturing the most pirates in the force. Now, Seina is no longer just the unfortunate boy from Earth; he is a man that pirates have come to fear. Despite his reputation, Seina is still the same clumsy guy, but at least he has Amane Kaunaq, a former model, and Kiriko Masaki, his long time friend, to keep him together. With their help, Seina sets out on an adventure in the hopes of becoming a great Galaxy Police Officer. [Written by MAL Rewrite]

The year is 1999. Amamori Hajime is just a normal, everyday elementary school student, trying to study and hanging out with his crazy pals. But then one day as his father is testing a piece of equipment he has been working on, something causes it to blow up, taking the house with it! Now orphaned, Hajime is taken in by his uncle, who is an astronomer. There at his uncle's observatory, he meets a girl he's seen before and developed somewhat of a crush on. He finds out her name is Yukino Yayoi, and her parents run a ramen shop in town. But even better than that, she's his uncle's assistant! What luck! But Yayoi isn't exactly what she seems. There is a reason she helps out Amamori-san at the observatory. She is the Millennial Queen (Sen-Nen Joou), specially chosen by her home planet, LaMetal, to go to Earth and help prepare for the possible annihilation of the planet. What will cause this disaster? LaMetal has an extremely elliptical orbit, which sends it very, very near Earth every 1000 years. When it gets close enough, the earth reacts, causing all sorts of natural disasters. Although she was chosen with the idea of protecting LaMetal in mind, her personal plan is to evacuate as many humans as she can to LaMetal, so if their planet is destroyed, they will survive. However, there is one person who strives to stop her plan, the head of the Millennial Theives. Why does he want to stop Yayoi? And how does he know about the Millennial Queen, anyway? (Source: AniDB)

Maeda Toshiie and Matsu visit Chousokabe Motochika, who governs Shikoku. They tell Motochika unreasonable demands from Nobunaga. Motochika rejects them and urges Maeda to betray Nobunaga. Meanwhile Keiji tries to convince Mouri Motonari to join the fight against Nobunaga, and is imprisoned as a result. Motochika and Motonari move against each other.

Chise is an ordinary schoolgirl: small, frail, and not particularly intelligent. Her greatest joy is her budding romance with her classmate and childhood friend, Shuuji. They both live in a small military town in Hokkaido, where high schoolers have few concerns other than who is dating whom and complaining about the steep climb up "Hell Hill" every day before school. One day, Shuuji and his friends make a trip to Sapporo to buy gifts for their girlfriends. A massive air raid on Sapporo that day kills thousands, including one of Shuuji's friends, and signals the beginning of a war. Fleeing from the carnage, Shuuji spots Chise, though now she has steel wings and a massive gun where her right arm should be. Against her will, she has been transformed into the ultimate cyborg weapon, capable of leveling entire cities. As the war rages closer and closer to their hometown, Chise and Shuuji's relationship is strained by her transformation, and they are left to wonder whether she is even still human. [Written by MAL Rewrite]