After defeating a mysterious enemy, Yuuma Tsukumo, along with the help of Kaito Tenjou and Ryouga "Shark" Kamishiro, has thwarted the Barians' plans. However, Yuuma is still on a quest to retrieve the Number Cards to restore Astral's memories. The Seven Barian Emperors catch wind of Yuuma and Astral's endeavors and begin to collect the cards themselves to achieve their ultimate goal: destroying Astral's world in exchange for saving their own. Though only five of the emperors are present, they unanimously decide on annihilating Astral and Yuuma once and for all. Elsewhere, with their newfound powers of ZEXAL, Astral and Yuuma work to eliminate the enemy force that threatens Earth and the rest of the universe. Yu☆Gi☆Oh! Zexal Second unveils the mysteries and unpleasant surprises that lie in the wake of Yuuma's adversities. As Astral struggles to accept his past and the consequences it may have brought, will the gods continue to shower their fortune upon Yuuma on yet another perilous adventure?

In 2024, the terrorist incident known as "The Laughing Man Incident" occurred in which Ernest Serano, president of the groundbreaking micromachine company, Serano Genomics, was kidnapped and ransomed. One day, the case having remained unsolved for six years, Detective Yamaguchi, who has been investigating "The Laughing Man Incident," sends word that he wants to meet with Togusa from Public Safety Section 9. However, soon after sending this message, Yamaguchi, crucial to the success of the case, dies in an accident. Many days pass and in the midst of a police interview relay concerning suspicions behind interceptors, a forewarning is received from "The Laughing Man" of his next crime. The incorporeal hacker begins to move once again. (Source: ANN)

A heated battle is once again revving up at Basara Academy between baseball star Masamune Date and soccer ace Yukimura Sanada. What's more, ever since student council chairman Hideyoshi Toyotomi received a suspension, leaving the seat up for grabs, a host of class "warlords" have become embroiled in a quest for supreme power. Amid Ieyasu Tokugawa's appeals to bonds of kinship and Mitsunari Ishida's fervor to defeat him, who will wrest ultimate control of the domain in "troubled" times? (Source: TBS Global Business)

The series is set in a near-future world where the boundary between human being and AI is vague. A rapid biological evolution, similar to "Cambrian Explosion," is caused by one incident. This incident turns into the genesis of a new jostle for supremacy, and the influence of the evolution goes beyond biological framework and spreads to various kinds of materials and technologies. The era of massive evolution involving diverse existences, such as human, machines, and biotechnologies, is coming. Characters fight an existential war in such a world. (Source: ANN)