In the dangerous suburbs of Chicago, skilled bounty hunters Irene "Rally" Vincent and "Minnie" May Hopkins run Gunsmith Cats, a firearms store of questionable legality. One day, Bill Collins, an agent for the Chicago branch of the Bureau of Alcohol, Tobacco, Firearms, and Explosives, blackmails Rally and May into working with him on a case. The stakes are high, but Rally’s gunmanship and May’s knowledge of explosives are unmatched. As Rally and May unravel the secrets of the case, the two will need to use guns and grenades while being faster, stronger, and better than everyone else in order to stay alive. [Written by MAL Rewrite]

"Mine has been a life of much shame."

Tokyo, 2036 (Showa year 111): a revolution in medical treatment has conquered death...
By means of internal nanomachines and the "S.H.E.L.L." system whose network controls them, human beings suffer no diseases, require no treatment for injuries, and are guaranteed a 120-year lifespan, free from illness. Yet this consummate social system warps the Japanese nation in a host of ways: unresolved economic disparities, ethical decadence resulting from deathlessness, grave environmental pollution, and the "Human Lost" phenomenon, in which people themselves, disconnected from the S.H.E.L.L. network, become malformed. Japan teeters wildly between two potential futures: civilization's restoration or its destruction.

Atmospheric pollution suffuses "Route 16" in the Outside—the area outside the Route 16 beltway. Youzou Oba, who lives an idle, drug-saturated life, joins Masao Horiki, a mysterious man who associates with the drag-racing gangs, on an incursion Inside—the area within the Route 7 loop where the privileged class lives—only to be embroiled in a violent struggle. When he encounters a malformed sufferer of the Human Lost phenomenon, a "Lost," Youzou's life is saved by Yoshiko Hiiragi, a girl of mysterious abilities who belongs to the anti-Lost agency H.I.L.A.M., and he discovers that he himself also possesses extraordinary powers...

Degradation and death. Life and hope. Buffeted by fate, a man tears himself apart and cries out. Rage. Sorrow. Pathos. Consumed by despair and bitter tears, Youzou Oba is himself transformed into a demon. A human lost... or a human who can find himself? 

(Source: Official Site)

Living an abnormal existence in Ogikubo, an intergalactic melting pot of humans and aliens as well as the only Space Immigration Zone on Earth, Luluco is a bubbly middle school girl who just wants to be normal. One morning, however, her father, who works at the Space Patrol, eats a volatile sleep capsule by mistake and is frozen solid! To make matters worse, Luluco accidentally breaks him, so she hurries off to his office for help. There, the chief of the Space Patrol, Over Justice, hires Luluco as a space temp worker for undercover investigations, so that the institution may crack down on crime within her school. Made to don the Space Patrol suit and sent on her way to mete out justice, Luluco attempts to maintain the image of a normal girl who does not stand out in any way. But she soon discovers that with the automatic systems and inherently zealous judiciousness of the Space Patrol suit, continuing to be normal will be more difficult than she thought. [Written by MAL Rewrite]

Special episodes added to DVDs and Blu-rays.