Kujo Jotaro is a normal, popular Japanese high-schooler, until he thinks that he is possessed by a spirit, and locks himself in prison. After seeing his grandfather, Joseph Joestar, and fighting Joseph's friend Muhammad Abdul, Jotaro learns that the "Spirit" is actually Star Platinum, his Stand, or fighting energy given a semi-solid form. Later, his mother gains a Stand, and becomes sick. Jotaro learns that it is because the vampire Dio Brando has been revived 100 years after his defeat to Jonathan Joestar, Jotaro's great-great-grandfather. Jotaro decides to join Joseph and Abdul in a trip to Egypt to defeat Dio once and for all.

In post-WWII Japan, Prof. Shikishima has built up Shikishima Industries to be a technological powerhouse, working on developing robots. However, at the heart of their success lurks a dark secret from the war, something that cost the life of Prof. Kaneda, the mentor of Prof. Shikishima. Now Kaneda's son, Shoutarou, is about to learn the truth, and it will change him forever. (Source: ANN)

Miaka and Taka (Tamahome's reborn out-of-the-book self) return to the Universe of the Four Gods to try and restore Tamahome's memories to Taka. This is not as easy as it sounds, however, when the evil Tenkou shows up to rain on their parade. He manages to thwart most of their attempts at getting Taka's memories back, and uses his newfound power to summon the Gods outside the book. (Source: ANN)

Keitaro has finally passed the entrance exams, and is officially a Toudai student. But after breaking his leg in an accident in the entrance ceremony, he thought and re-evaluated himself. Having new goals, Keitaro follows Seta on an overseas archeology trip. During his absence, however, all was not well in Hinata Lodge. Urashima Kanako, Keitaro's sister, arrives on the scene. She claims to be the new manager of Hinata Lodge starts to go against all the tenants. Things become even more complicated when they recieve a letter from Keitaro. The tenants and Kanako made a big mess trying to get the letter, but Seta's car crashes in before anyone could read the letter...