Onboard a cruise ship heading to the scenic Cenancle Island, the full-body cyborg Nene Nanakorobi, a bubbly young girl who dreams of world peace, meets inventor Uzal Delilah. The two become fast friends along with Uzal's pet cyborg Clarion, a cat-like combat android. Soon after parting ways, a terrorist attack on the island threatens to shatter the pair's new friendship. In a bid to save her new friend, Uzal gives Nene the ability to use the Pandora Device found in Clarion's body before seemingly dying. With this power, Nene can temporarily master abilities and skills never seen before in the advancing world. Working together, the two unlikely companions go on various missions—from saving children in shopping mall fires to fighting reckless thieves—all in the name of world peace. But to achieve this goal is not easy. B.U.E.R, a sentient laser in the form of a misshapen teddy bear, threatens to wreck their happy lives with his perverted nature and uncontrollable power. And to make matters worse, Nene's guardian, as well as genius inventor, Takumi Korobase has an undying interest in B.U.E.R. Burdened with saving the world and keeping B.U.E.R from the hands of evil, Nene and Clarion's desire for world peace seems like a pipe dream. With this monumental goal, could the weight of it all destroy the pair's friendship completely?

The series is set in the distant future in which the Earth is split in two. The southern hemisphere is placed in another dimension while the inhabitants of the northern hemisphere are able to morph into beast-like humanoids. Eventually the humans of the southern hemisphere, led by Uranus, attack the Beasts. The Three Beasts, Wan Derbard (Wan Dabadadatta) of the Tiger Tribe, Bud Mint (Baado Mint) of the Bird Tribe, and Mei Mer (Mei Mah) of the Mermaid Tribe, are taken prisoner along with Mei Mer's companion Tuttle Millen (Mekka Mannen, also of the Mermaid tribe), but manage to escape thanks to a little girl named Yuuni Charm Password. Together they seek Gaia, which they believe to be a fabulous treasure, but they are pursued by Uranus's minions : V-Darn the vicious mage-knight, V-Sion the warrior woman and Akumako, V-Darn's sadistic imp-like partner.

Emi is a seventeen-year-old girl living in Shibuya. Her father is always away with work and she's grown listless. Suddenly, a twist of fate involving a certain magical item changes everything. A mysterious pencil, of all things, is linked to the appearance of heroes from another world! Could this be the start to the excitement she's so desperately craving, or is there something more?

Short specials included on the BD/DVD volumes of Freezing Vibration.